How to beat Ramón in Resident Evil 4, Ramón Salazar boss strategy

Ramón Salazar is the boss near the end of Chapter 12 of the Resident Evil 4 remake.

You’ll want to bring the ideal weapons and use the best strategy to conserve your health and ammo to take on Ramon in Resident Evil 4, especially on Extreme and Professional difficulties, since it’s a long battle.

To help you finish Chapter 12, below we detail the best strategy to defeat Ramón Salazar.

Please note that this is a guide for the new version of Resident Evil 4, so the exact boss strategy may not be the same in the original version.

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For more help, you can visit our Resident Evil 4 walkthrough.

How to beat Ramón Salazar in Resident Evil 4

Here’s our strategy for Resident Evil 4’s Ramón Salazar boss:

Preparing for the Ramón Salazar fight

Depending on what you’ve upgraded and how much ammo you have, there are a few different weapon options we recommend bringing into the fight with Ramon.

If you have it and want to shorten the length of the fight with Ramon (and boy is it long), then the best weapon to use is the Broken Butterfly Magnum. However, we only recommend this as a last case, as ammo is very limited for this powerful weapon and you may want to save it for another boss fight.

If you are not using the Magnum as your primary damage dealer, we suggest bringing a rifle like the CQBR assault rifle or a bolt-action rifle with a scope. Improving the damage of the gun you choose is also a good idea. Of all the pistols, the Red9 with the stock is the one we like the most, since it acts as a kind of minigun in the form of a pistol, due to its power and effectiveness at long range.

Grenades and a shotgun can help in the rare cases when Ramon is on the ground, but the shotgun is not an essential weapon that must be upgraded to defeat Ramon.

As with all of our boss guides, we also recommend that you make sure you have amulets equipped that increase your healing from fish, eggs or vipers if you have any of them to spare in your inventory. However, the amulets are random rewards from the shooting range, so you may not have any healing ones before the fight with Ramon.

If you do not have these items or amulets, we recommend purchasing a first aid spray from the merchant if you can afford it. The merchant refreshes his stock of first aid spray fairly regularly throughout the game, so if you have the space (and don’t mind spending the money), it’s always nice to have extra healing before a boss fight.

Strategy to fight against Ramón Salazar – Phase 1

As with many of the bosses in the Resident Evil 4 remake, we suggest you first break all the boxes and barrels in the boss arena to get all the resources you may have. They contain ammo, health items, and crafting resources, but keep in mind that their content is randomized for each encounter.

For the fight itself, you should stay on the side with the spine intact, as by hiding near it you will be able to avoid most of Ramon’s acid spray attacks.

During the first phase of the fight with Ramon, his acid sprays come in two forms: a continuous spray with a stream and a spray similar to a shotgun blast that covers a wider area. Make sure you are close to the pillar and when you see Ramon, he starts an acid attack, hide at an appropriate angle.

An example of the annoying shogun explosion type acid spray.

Between his acid sprays, you’ll need to shoot Ramón’s yellow eye or body with your rifle or pistol. The ideal is to hit the eye, but it is much more difficult, since Ramón likes to move very quickly through the sand.

We didn’t find flash grenades particularly useful, as they don’t stun Ramon for long enough to allow you to deal a significant amount of damage. However, they can be used as a last resort if you can’t hide behind the pillar in time when Ramon starts an acid spray, while Flash Grenades stops his acid attack.

There’s not much else to the fight other than hiding and shooting when you can. Then, when Ramon has taken enough damage, he will fall and you can press the knife button or unload your most powerful weapons into his eye. This is where you should use the Magnum, Shotgun, or Grenades, depending on what you are using as your main damage dealer.

Keep in mind that Ramon is probably the longest boss fight in the game, so even if the battle doesn’t seem to progress, you’re chipping away at his health.

Strategy to fight against Ramón Salazar – Phase 2

Once you’ve damaged Ramon enough, he’ll enter his second phase and add a vertical acid spray attack to his arsenal. To avoid this continuous spray, hide under the platform attached to the intact column.

Hide under this platform to avoid Ramon’s vertical acid spray.

The strategy to damage Ramón during his second phase is the same as in the first phase: shoot his yellow eye, or Ramón’s body with your rifle or pistol, while hiding from his acid sprays.

However, the main differences during phase 2 are that Ramón is much faster and more aggressive with his attacks, and that he will launch small blobs that will explode if you get too close to them, so you have to be aware of where you are. We are walking at all times.

These bubbles glow red when they are about to burst.

The good news is that you can shoot these blobs to get more resources for the fight, including ammunition and health items. Instead, Ramon’s acid spray will sometimes make these droplets explode.

Ramón also positions himself a lot more on the ground during the second phase, but unfortunately this is usually not enough time to deal much damage with weapons like the magnum or shotgun. Still, be sure to take advantage of these opportunities when you can!

You’ll get Ramon’s Lip Rouge for defeating him, which can be sold to the Merchant, and if it’s your first time facing Ramon, you’ll also get the “No thanks, bro!” Trophy or achievement.

Our Resident Evil 4 walkthrough can help you through the village with guides on the Big and Little Cave Shrine puzzle solutions, the Church dial puzzle, and the Del Lago, El Gigante, and Mendez bosses. When you reach the castle, you’ll need to tackle the correct timing puzzles of the Treasure Sword, the Four Slotted Wall, the Dining Room Bell, and the Grandfather Clock, along with the Garrador Dungeon, Two Giants, and Ramon Salazar’s bosses. The island is next, and there are still puzzles with calibration puzzles, keycard locations, and a hidden wrench, along with final bosses Krauser and Sadler.

Fighting Ramón Salazar in Hardcore or Professional

There isn’t much difference in strategy when fighting Ramon on Extreme or Professional difficulty – Ramon’s increased health simply adds even more time to this already long battle!

The only thing we recommend doing differently is shooting Ramon when he’s down with your most powerful weapons, instead of stabbing him, unless you’re sure you can survive the long fight.

Also, remember that if you play on Professional, you must manually save right before the fight, since there is no autosave.

Good luck taking on Ramón!

If you want more help with Resident Evil 4 remake, you can visit our walkthrough for more puzzle solutions, boss guides, and Ask for Help.

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